The picoZ80 is a custom PCB designed to replace a physical Z80 in a host or industrial computer with a faster CPU, more memory, virtual devices, networking, and rapid application loading from an SD card. It hosts an RP2350B microcontroller, a dual-core 150MHz Cortex-M33 device capable of running at up to 300MHz, and an ESP32 co-processor for WiFi and Bluetooth connectivity.