Google DeepMind Releases AlphaGenome Atlas

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Scientists have developed the AlphaGenome Atlas, a database predicting effects of single nucleotide variants in the human genome. The Atlas helps researchers quickly prioritize promising research areas by providing an easy-to-use score for coding and non-coding regions.

DaVinci Resolve 21.1

Media

LibreOffice breaks download records after declaring it has no AI features

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LibreOffice 26.8, a free alternative to Microsoft Office, reached a record download of over 1 million times in one week due to its writing system and typography improvements. The Document Foundation clarified that LibreOffice does not include generative AI features due to privacy concerns and principles it has set for itself.

ZX Spectrum: Experimenting with 1-Bit Sound

The author implemented a 1-bit PCM playback system on the ZX Spectrum, which uses cycle counting to generate sound. The system produces poor quality audio due to the limitations of the 1-bit speaker, but it can be used for simple tones and chords.

Show HN: Copperhead – Hardware as Fast as Software

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Copperhead is an open-source AI platform for designing and verifying printed circuit boards. It helps hardware teams by automating the design process, ensuring consistency and accuracy.

Benchmarking Qwen3.8 27B quantizations: 4-bit holds up, 1-bit collapses

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The author tested various GPU RAM requirements for running Qwen3.8 27B without sacrificing quality, finding that a 24 GB card like RTX 4090 can handle the full BF16 model with some context reduction.

How Climate Resilient Are the Largest Cities?

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The report analyzes 72 cities' climate risk and resilience using AlphaGeo's Climate Risk & Resilience Index (CRRI), revealing that European, African, and Latin American cities are more resilient than South Asian megacities.

The two Christian saints who are the Buddha

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The story of saints Barlaam and Josaphat originated from an Arabic version of the Buddhist tale, with similarities to the life of Gautama Buddha, and was later adopted by Christian churches. The shared themes across different faiths highlight a common human experience that transcends individual eras and places.

Disappointed Optimists

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The author discusses the "cursed problem" of designers being asked to change people's behavior for profit, and how this conflict can lead to disappointment and burnout. They suggest that designers must decide which promise they can live without in order to find a compromise.

Among European Companies That Use a CDN, Nearly 9 in 10 Use Cloudflare

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Cloudflare is the majority front door for 89.6% of European companies with a CDN, while Amazon comes second at 3,112 distinct companies.

DHS 'Predictive Policing' Unit Is Analyzing Americans' Financial Habits

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Border Patrol's Predictive Intelligence Targeting Teams (PITT) analyze Americans' financial activity and other data to identify potential targets for traffic stops, raising concerns about civil liberties. The program has led to innocent people being pulled over and questioned, sparking calls for greater oversight and accountability.

Antiquated HTML Snippets and Artefacts

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The web has undergone numerous changes due to evolving devices, browsers, and personal preferences. Various non-standard HTML tags have been used to adapt websites for different environments and integrations.

Paramount Caught Using 'Astroturf' Group to Drum Up Fake Support for Merger

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Paramount's $111 billion merger with Warner Brothers is criticized for its negative impact on labor, consumers, and markets. The company has employed astroturf tactics to create a false grassroots movement in support of the deal.

Reverse engineering the 2008 LogiCola, a logic drill program

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LogiCola 3 now supports offline use and includes improved accessibility features based on user feedback. The redesign balances modern aesthetics with the original's playful elements, using color schemes and patterns inspired by Gensler's work.

AlphaGenome Atlas predictive map of every DNA letter change in the human genome

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Google has introduced AlphaGenome Atlas, a platform predicting the molecular impact of every possible single-letter DNA variant in the human genome. This comprehensive catalogue will help accelerate our understanding of biology and treat disease by providing researchers with an intuitive and free-to-use website portal.

The Helicopter with Radioactive Blades

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The CH-53 Sea Stallion helicopter uses a simple mechanical system to detect rotor blade cracks, involving ionizing radiation from Strontium-90. This method has been effective for decades and is still used today in newer models with fiber optic sensors.

Extracting Steering Vectors from J space

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The user tested using the Jacobian space to derive steering vectors from concept tokens for simple model behaviors like generating all caps or refusing prompts, but found it prone to hallucinations and brittle.

I've factored the RSA keys of a Certificate Authority from the 90s

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The author explores the security of RSA cryptography, noting that small keys can be factored on a modest desktop computer and some old root certificates are still vulnerable.

There's a new "Google Jail" for independent wikis

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The author is discussing the challenges of hosting video game wikis on new domains after a Google core update in March 2024, which has made it difficult for these wikis to show up in search results. The author is exploring possible solutions and potential long-term fixes to this issue.

The 92-Year-Old Mathematician and the Teenage Apprentice

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US police fear Meta smart glasses could be used to secretly record them

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Law enforcement agencies across the US are concerned about Meta's camera-equipped smart glasses being used to secretly record them or aid in terrorism, prompting memos from departments in Maine to California. The technology has raised fears of surveillance and impunity among police and public alike.

Mistral raises €3B

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Mistral raised €3 billion in a Series D funding round, valuing the company at over €21 billion. The investment will help Mistral expand its frontier research and infrastructure to support mission-critical AI transformation for global enterprises.

Picolibrary: A Small Press

The author has successfully republished a book, "Professor Mmaa's Lecture", after inquiring about the rights and obtaining a new contract. The process involved scanning the original 1953 edition, OCRing the text with LLMs, and formatting for ebook publication.

Ask HN: Are others seeing Google's reCAPTCHA rejecting Firefox users?

User is experiencing an infinite Google reCAPTCHA loop while accessing archive.is in Firefox on Linux, despite disabling Privacy Badger and trying private browsing. The issue may be related to a configuration problem or a change made by archive.is.

Why getting your hands dirty is good for you

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Touching natural materials like soil and plants can boost skin's microbial diversity, benefiting the immune system. Research suggests that prolonged or frequent contact with nature could significantly change what's happening on our skin and in our bodies.

TALA Is Open-Source

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TALA, an auto-layout algorithm, is now open-source under the same license as D2. It offers a novel orthogonal layout engine with customizable node positions and sizes for various use cases.

End-to-end infrastructure for training and inferencing open weight models

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AC2 is a researcher cockpit for model development and learning, with options to use coding agents or follow the Quickstart. It includes an OpenTelemetry-based observability SDK called ac2.tracing for capturing timing and other metrics.

We built our house for LAN parties (2024)

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Kenton Varda and Jade Wang, a married couple with two kids, designed and built their house from scratch in Austin, Texas. The house features custom-built gaming stations with 22 game machines that cost around $75,000.

How well do agents use test/verification techniques?

Agents were given various instructions to test code, but most failed to use the techniques effectively. Default performed better than most conditions due to agents not doing useless work when not instructed.

Arm Mali G2-Ultra NX GPU: desktop-class mobile gameplay with AI-native graphics

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The Arm Mali G2-Ultra NX GPU brings dedicated neural accelerators and a new execution engine to create desktop-class gaming experiences on mobile devices. It integrates neural graphics capabilities, such as Neural Super Sampling and Denoising, into the graphics pipeline for improved efficiency and image quality.