Researchers found that adding an experimental drug, bepirovirsen, to standard antivirals cured 19% of people with hepatitis B virus in two trials. The results are promising but may not be effective for the majority of the 240 million people worldwide living with chronic HBV infections.
The APC-2 is a professional record cutter with superior sound quality, available exclusively through SUPERSENSE. It features advanced technology for precision cutting and control.
The author of Have I Been Pwned reflects on the 1,000th breach loaded into the database, questioning its continued purpose due to emerging privacy regulations. Disclosure lag times for breaches are worsening, with companies taking months to notify victims.
A perceptron is a simple neural network that takes one input, weighs it with a weight, adds a bias, and decides with a yes-or-no answer, and it learns from its mistakes by adjusting the weight and bias. The perceptron's ability to learn and make decisions relies on the weight, bias, learning rate, and normalization of the input data, which can be adjusted to improve its accuracy and performance.
The user spent 14-16 years in juvenile prison and later became a convicted felon due to addiction, but rebuilt their life through software and open-source contributions. They now work at Hasura, a developer-facing tool, and hope to give others a chance despite their troubled past.
Employers rely heavily on hiring algorithms, but a study of 3.4 million job applicants found large-scale racial disparities and homogeneous outcomes. Algorithmic monocultures in hiring yield systemic rejections, with 25.87% of Black and 14.74% of Asian applicants facing adverse impact.
You coined the term "dopamine fracking" to describe the harm caused by prioritizing short-term dopamine hits over long-term cultural and personal sustainability. This phenomenon erases complexity and nuance, replacing it with a homogenized, commodified culture devoid of meaning and connection.
The One World Flag represents unity and a shared home for all inhabitants of the blue planet. It symbolizes that more unites us than divides us, promoting a sense of belonging and togetherness.
DeepSeek V4 Pro wins this head-to-head by being more exact where it matters: following instructions, matching schemas, and solving edge cases cleanly. GPT-5.5 Pro is still strong, but it gave away points with avoidable deviations.
This repository contains Rust examples for the Raspberry Pi Pico 2 using Embassy async framework, including sensors and displays. Examples include ADXL345 accelerometer, DS18B20 temperature sensor, DHT11 temperature and humidity sensor, and more.
The author created a pancake calculator to optimize pancake recipes by balancing four axes of quality: interior texture, tang, rise, and exterior crisp. The calculator uses stoichiometry to determine the optimal ratio of ingredients, including acid, leavening agents, and dairy, to create the perfect pancake.
The writer is unable to pursue snowboarding due to knee issues, but has come to accept and move on from the dream. They now focus on their current life and hobbies, finding satisfaction in the present moment.
YouTube channels you add here stay on this device. Your phone, laptop and your kids iPad can each have their own list, you choose what each one is for. Come when you feel like it. Watch what you chose. Close it and move on. No notifications Β· No autoplay Β· No recommendations Free to use Β· No credit card ever needed Paste a YouTube channel URL directly, search sometimes misses niche or newly ...
Last time, we looked at the rotation algorithm used by gcc libstdc++ for random-access iterators, and I concluded by noting that weβre going to make a shocking discovery. The discovery is that the gcc libstdc++ algorithm is the same as the forward-iterator algorithm! Letβs run both algorithms on a problem where the two blocks are A1, A2, A3, B1, B2, B3, B4, B5. Iβll put the old forward ...
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Linear's speed comes from its local-first architecture, where the browser stores data and syncs with the server in the background. The app's design, including shortcuts and animations, also plays a crucial role in making it feel fast and responsive.
A magnitude 7.8 earthquake struck the southern Philippines on June 8, 2026, causing damage and a tsunami warning in General Santos city. No casualties were reported but a small building collapsed and aftershocks followed.
J.C.R. Licklider proposed the concept of man-computer symbiosis in 1960, where humans and computers work together to solve complex problems, with the computer handling routine tasks and the human providing goals, hypotheses, and evaluations. To achieve this symbiosis, significant advancements in computer technology, including memory organization, programming languages, and input/output ...
Weaker isolation levels in databases can lead to concurrency bugs and security vulnerabilities, as seen in cases like Flexcoin and Poloniex. Using serializable isolation as the default can prevent such issues.
The /lost+found/ folder in Linux and Unix is for storing files that fsck, the filesystem check and repair command, recovers from a damaged filesystem. You would interact with it after a system crash or power failure, when fsck places recovered files there.
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Lathe is a tool that generates hands-on technical tutorials on demand using LLM skills, allowing users to learn by working through tutorials themselves. It's a combination of LLM skills and a Golang CLI used to store, manage, and view generated tutorials.
IOCCC29 had a high submission quality and similar volume to last year, possibly due to improved website design and social media presence. The contest's rules and guidelines were rewritten for this year, and the next contest, IOCCC30, is planned for late 2026.
IBM introduced the Electronic Calculating Punch, type 604, a programmable calculator that used vacuum tubes and was much smaller and cheaper than computers. It was highly successful, with over 5600 units produced, and led to the development of IBM's vacuum-tube computers in the 1950s.
The user, a 10-year experienced software engineer, is concerned that their domain expertise in finance and payment processing is becoming less valuable due to advancements in AI and LLMs, which can now perform tasks such as writing code and debugging. The user is worried about their long-term employability and is considering shifting their domain expertise to areas where LLMs are not yet ...
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2026-06-07 17:31:21 UTC
ycombinator.com
Llama
Proliferate is building an operating system for modern engineering, automating software development to make engineering more human. They're hiring an engineering lead to build the core product with high ownership and a top-market salary.
The user is frustrated with expensive Sennheiser wireless microphone battery packs and decided to replicate them using 3D printing and third-party cells. They successfully created a working battery pack.
The user's AI development process involves automated doubt from multiple perspectives to ensure quality, using subagents to critique and audit artifacts. This process originated from a lack of trust and has developed into a trust signal, requiring patience, practice, and expertise to terminate the loop.
Each digit represents a different colour channel: red, green, and then blue. the restriction has made me more open to errors and it's totally fine. 900 has full red channel (9) and nothing in green (0) or blue (0). so in my theme, 00 is... off-black. so you can just use lookup table if you want. click here to download the theme - it's free to use and works
Mike Kirtner, president of Kindred Communications, reported an FM transmission line was cut in broad daylight at 93.7 WDGG(FM) in Ashland, Ky. The station is operating at reduced power and estimates total repair costs between $70,000 and $100,000.