Couple pay >$800k for a gene-editing therapy for their daughter. She died.

A 6-year-old girl named Mei underwent an experimental gene therapy at Xinhua Hospital in Shanghai to treat her rare genetic disorder. Mei died 7 days after receiving the treatment due to a severe immune reaction.

Writing by hand is good for your brain

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Writing by hand with a fountain pen on paper can be beneficial for the brain and reduce fatigue, but it requires finding the right balance of friction and using the right type of paper. To get started, consider using a fountain pen with a fine nib on inexpensive paper and gradually move to more expensive pens and paper as you develop your writing style.

Show HN: Echo – Fable-level results at 1/3 the cost using open-weight models

The user built Echo, an AI system that combines multiple open-weight models for better performance, allocating computation and combining outputs based on each request. Echo outperformed individual models and reached similar results to Fable at lower inference cost, but still has limitations and failure cases to be addressed.

Namecheap Gave My Account to an Unverified Third Party Just Because They Asked

NameCheap customer had account compromised after incoming club leader convinced support to change password and email address without verification. The customer believes this is a massive vulnerability and has moved critical domains out of NameCheap due to ease of account takeover.

The Beam Engine

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The beam engine, developed by Thomas Newcomen and improved by James Watt, used steam to drive a piston and ultimately turn a crank, producing power for the Industrial Revolution. Watt's innovations, including the double-acting engine and the parallel motion, increased efficiency and allowed the engine to power machinery directly, revolutionizing industry and manufacturing.

What happened to TheNumbers.com

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The Numbers, a film industry data website, was severely impacted by AI traffic and a potential cyberattack, leading to a week-long outage and significant changes to its infrastructure. The site's founder, Bruce Nash, attributes the issues to the increasing strain of AI bots and automated traffic, which now make up 90% of the site's traffic.

Startup founders urge U.S. government not to shut off Chinese open weight AI

Silicon Valley startup founders are urging the Trump administration not to block access to Chinese open-weight AI models, warning that a ban would cripple US startups. They propose targeted safeguards instead of broad prohibitions to address security concerns.

Building on ATProto

The user wants to build a suite of applications for recording reviews that allow users to choose how public or private they want their reviews to be, but is disappointed with the current design of ATProto, which assumes everything will be published online and doesn't support access control or private data. The user believes ATProto has the potential to be a new protocol empowering users, but ...

98.css

98.css is a CSS library for building interfaces that look like Windows 98. See more on GitHub. This library relies on the usage of semantic HTML. To make a button, you'll need to use a <button>. Input elements require labels. Icon buttons rely on aria-label. This page will guide you through that process, but accessibility is a primary goal of this project. You can override many of ...

Software rendering in 500 lines of bare C++

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The goal is to create a simplified 3D graphics API clone from scratch using OpenGL, Vulkan, Metal, and DirectX, focusing on understanding the underlying concepts rather than writing GPU applications. The initial task involves creating a software renderer that can load a 3D model and render it to an image file, starting with basic functionality to set pixel colors.

Learn OpenGL, extensive tutorial resource for learning Modern OpenGL

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This online book teaches modern OpenGL basics, intermediate, and advanced knowledge in an easy-to-understand format with clear examples. It's free and available online, with a physical copy also available for purchase.

A solid-state β€œatomic channel” for separating rare earth elements

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Researchers at the University of Chicago and Northwestern University discovered a cleaner method to separate rare earth elements using a layered form of manganese oxide. The new approach relies on electrochemical intercalation and can differentiate rare earth elements in water without organic solvents.

Show HN: Palmier Pro – Open-source macOS video editor built for AI

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Palmier Pro is an open source Mac video editor that integrates AI into the workflow. It allows users to generate and edit videos with SOTA models and connect with agents like Claude/Codex/Cursor via MCP.

Astronomers may have found the first exomoon

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Astronomers have discovered a moon-like object in the CD-35 2722 system, which orbits a brown dwarf, not a planet. This object is at least as massive as Jupiter and is difficult to label due to the system's unique characteristics.

Interview with Matheus Moreira about Lone Lisp and Linux Kernel

Alex Alejandre Matheus Moreira built Lone Lisp, a language directly on Linux system calls, and shares his knowledge of C and the Linux Kernel. He started learning programming through video games, specifically the Mega Man Battle Network series, and eventually learned various languages including C++, Java, Ruby, and Lisp, before creating Lone Lisp as a freestanding language with a focus on ...

DARPA, U.S. Air Force fly AI-controlled F-16

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A US Air Force F-16 fighter jet has undergone in-air testing using an AI agent to autonomously control flight, advancing combat AI development. The VENOM program, a joint effort between the US Air Force and DARPA, aims to develop trusted, autonomous air combat capabilities.

A Taxonomy of Omnicidal Futures Involving Artificial Intelligence

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This report presents a taxonomy and examples of potential omnicidal events resulting from AI: scenarios where all or almost all humans are killed. These events are not presented as inevitable, but as possibilities that we can work to avoid. Insofar as large institutions require a degree of public support in order to take certain actions, we hope that by presenting these possibilities in ...

Converting Files into Minecraft Worlds

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The user created a program to convert any file into a Minecraft world by mapping each byte to a block and placing them in a 16x16x16 cube. The program can now read and write .mca region files, allowing for large multi-region worlds to be encoded.

Launch HN: Screenpipe (YC S26) – Record how you work and turn that into agents

Louis built Screenpipe, an app that records screen and audio locally to give AI agents a searchable memory of user activity, making it easier to automate tasks and create SOPs. Screenpipe's AI-friendly API allows users to interact with their recorded data through various agents, with a free tier and commercial plans available, including an enterprise plan for discovering automation opportunities.

The arguments against open source AI are bad

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The debate over open-source AI models is misguided, as history shows that suppressing open-source software is difficult and only weakens companies against international competitors. Open-source AI models can benefit the US economy, as they can be developed by various commercial actors, including American startups and chip makers, and can lead to innovation and growth.

Geekbench 7

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Geekbench 7 is a new version of the cross-platform benchmark that measures CPU and GPU performance with improved workloads. It includes new media workloads, a Game Physics workload, and updated data sets to better reflect real-world tasks and applications.

Building watchable digital twins of 64 World Cup games

Learn WebGPU for C++

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This guide explains how to create native 3D applications in C++ using WebGPU graphics API for Windows, Linux, and macOS. It's still under construction and uses outdated code in some sections.

Show HN: Trifle – Open-source analytics that stores answers, not events

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Trifle provides visibility into pricing pipelines and catches anomalies before customers notice. It offers a combination of big-picture data and individual job execution details through Stats and Traces.

Escape Analysis in Go: Stack vs. Heap Allocations Explained

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The Go compiler uses escape analysis to determine whether a value can be allocated on the stack or must be moved to the heap, and understanding this process is a must-have skill for any Go developer. By using the GoLand escape analysis tool or the -gcflags debug flag, developers can inspect the compiler's output to identify patterns and optimize performance-critical code.

Fields Medals 2026

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The Fields Medal is awarded for outstanding mathematical achievement and future promise, funded by a trust established by J.C.Fields. The 2026 prize winners were recognized for their work in partial differential equations, symplectic geometry, arithmetic and complex algebraic geometry, and harmonic analysis.

JEP 540: Simple JSON API (Now in Incubator)

The Java Platform is introducing a new standard API for parsing and generating JSON documents, aiming to provide a simple and easy-to-use interface for common tasks, without requiring an external library. The API is designed to be strict and conform to RFC 8259, with a focus on machine-to-machine communication, and will be incubated in the JDK with the goal of eventually becoming a standard ...

AI Companies Are Trying to Hide a Staggering Amount of Debt

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Tech giants like Alphabet, Microsoft, and Meta are hiding $1.65 trillion in debt off their balance sheets, using special purpose vehicles to make their financial reporting appear healthier. This has experts warning of an AI bubble and increased vulnerability if the industry fails to generate demand to justify massive data center investments.

Meta Garbage Collection: Using OCaml's GC to GC Rust

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Soteria Rust, a symbolic execution tool, experienced quadratic time complexity due to its Tree Borrows implementation, but was fixed by delegating garbage collection to OCaml's garbage collector, resulting in a 10x speedup. The fix involved implementing a "backoff" mechanism to run the OCaml garbage collector periodically when the tree exceeded a certain size, achieving linear execution time ...

Emacs Is a Lispboard

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Emacs is a Lispboard, a working environment that integrates multiple programs, allowing users to work in a single place with a layout system and an embedded scripting language. Its rival is the web browser, but Emacs offers more flexibility and control, making it a unique and powerful tool for users.